THIRD-PARTY T CELL IMMUNOTHERAPY FOR VIRAL INFECTIONS IN PRIMARY IMMUNODEFICIENCY DISORDERS
نویسندگان
چکیده
منابع مشابه
stem cell transplantation for treatment of primary immunodeficiency disorders
primary immunodeficiencies constitute a group of highly complex congenital disorders most of which are characterized by a very poor prognosis. allogeneic hematopoietic stem cell transplantation (hsct) has become an established curative treatment approach in many of these disorders, which may be permanently corrected. in this presentation basic and practical aspects of hsct are presented, with a...
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Restoration of antigen-specific T cell immunity has the potential to clear persistent viral infection. T cell receptor (TCR) gene therapy can reconstitute CD8 T cell immunity in chronic patients. We cloned 10 virus-specific TCRs targeting 5 different viruses, causing chronic and acute infection. All 10 TCR genetic constructs were optimized for expression using a P2A sequence, codon optimization...
متن کاملAdoptive T-cell immunotherapy from third-party donors: characterization of donors and set up of a T-cell donor registry
Infection with and reactivation of human cytomegalovirus (CMV), Epstein-Barr virus (EBV), and adenovirus (ADV) are frequent and severe complications in immunocompromised recipients after hematopoietic stem cell transplantation (HSCT) or solid organ transplantation (SOT). These serious adverse events are associated with significant morbidity and mortality. Donor lymphocyte infusions (DLIs) are o...
متن کاملT-cell therapy for viral infections.
Viral infections remain a major cause of morbidity in patients with immunodeficiency, such as recipients of hemopoietic stem cell transplantation. Adoptive transfer of donor-derived virus-specific cytotoxic T lymphocytes is a strategy to restore virus-specific immunity to prevent or treat viral diseases and has been tested in the clinical setting for more than 20 years. Several different groups...
متن کاملself-revision and third party revision in translation
اهمیت این پژوهش در آن بود که به گفت? بسیاری از پژوهشگرانِ حوز? بازبینی ترجمه، ادبیات موجود در این زمینه به لحاظ نظری و عملی چندان قوی نیست و بخش های موجود نیز برداشت مناسبی از این مرحل? فرایند ترجمه ندارند، اگرچه اخیراً توجه به آن به صورت نظام مند افزایش یافته است. در عین حال، پژوهش های موجود از یک سو بر دگربازبینی بیشتر از خودبازبینی تأکید دارند و از دیگر سو تنها به لحاظ نظری به این موضوع می پرد...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2018
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2017.12.626